Apr 3, 2018. European Institute for Molecular Imaging, University of Mnster, D-48149 Mnster, Germany, Roche Innovation Center, Early Clinical Development Oncology, Roche Pharmaceutical Research and Early Development, CH-4070 Basel, Switzerland, Department of Nuclear Medicine, University Hospital Mnster, D-48149 Mnster, Germany, Department of Nuclear Medicine, University Hospital Bonn, D-53127 Bonn, Germany, Department Radiology & Nuclear Medicine, Amsterdam UMC, Vrije Universiteit, De Boelelaan 1117, 1081HV Amsterdam, The Netherlands, In Vivo Cellular and Molecular Imaging Laboratory, Vrije Universiteit Brussel, B-1090 Brussel, Belgium, Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge CB2 ORE, UK, Biomarkers and Translational Technologies, Pharma Research and Early Development, F. Hoffmann-La Roche Ltd., CH-4070 Basel, Switzerland, Department of Geriatrics and Neurology, Johanniter Hospital, D-53113 Bonn, Germany, Centre of Integrated Oncology, University Hospital Bonn, D-53127 Bonn, Germany. The unique potential of Radiopharmaceuticals in treating . The drugs used for diagnosis are called as tracers. Patient-reported quality-of-life analysis of radium-223 dichloride from the phase III ALSYMPCA study. ; Dillon, J.S. Most of the tumor cells also express CXCR4 and the receptor supports proliferation, angiogenesis, survival, and metastasis formation. New developments in the production of theranostic pairs of radionuclides. injection of vectors that give constitutive and widespread expression. 1991 Feb 15;67(4 Suppl):1261-70. doi: 10.1002/1097-0142(19910215)67:4+<1261::aid-cncr2820671524>3.0.co;2-l. Curr Drug Targets. The 68Ga/177Lu-theragnostic concept in PSMA-targeting of metastatic castrationresistant prostate cancer: Impact of post-therapeutic whole-body scintigraphy in the follow-up. Advanced Prostate Cancer Consensus Conference 2019; Basel, Switzerland; Aug 2931, 2019. https://www.mdpi.com/openaccess. Evaluation of [89Zr] trastuzumab-PET/CT in differentiating HER2-positive from HER2-negative breast cancer. Improving external beam radiotherapy by combination with internal irradiation. The current status and future potential of theranostics to diagnose and treat childhood cancer. ; et al. Single photon emission computed tomography and positron emission tomography in cancer imaging. Poeppel, T.D. ; Serganova, I.; Hricak, H.; et al. ; Hershman, J.M. Heidari, P.; Kunawudhi, A.; Martinez-Quintanilla, J.; Szretter, A.; Shah, K.; Mahmood, U. Somatostatin receptor type 2 as a radiotheranostic PET reporter gene for oncologic interventions. Radioimmunotherapy with iodine (131)I tositumomab for relapsed or refractory B-cell non-Hodgkin lymphoma: updated results and long-term follow-up of the University of Michigan experience. To read this article in full you will need to make a payment. Additionally, there are now seven well-defined human reporter genes, including hNIS, hNET and hSSTR2 with complementary radiolabeled marker substrates available for clinical application; hNIS being the best characterized for theranostic applications and hNET being the most sensitive system to detect transduced cells. Disclaimer. Improved herpes simplex virus type 1 amplicon vectors for proportional coexpression of positron emission tomography marker and therapeutic genes. Development of Lu-177-trastuzumab for radioimmunotherapy of HER2 expressing breast cancer and its feasibility assessment in breast cancer patients. A novel 111In-labeled antiprostate-specific membrane antigen nanobody for targeted SPECT/CT imaging of prostate cancer. Diagnostic performance of 68Ga-PSMA-11 (HBED-CC) PET/CT in patients with recurrent prostate cancer: Evaluation in 1007 patients. 2022; 15(1):13. ; Beerens, C.E. DHuyvetter, M.; De Vos, J.; Caveliers, V.; Vaneycken, I.; Heemskerk, J.; Duhoux, F.P. Sathekge, M.; Bruchertseifer, F.; Knoesen, O.; Reyneke, F.; Lawal, I.; Lengana, T.; Davis, C.; Mahapane, J.; Corbett, C.; Vorster, M.; et al. ; Kulke, M.H. ; Nijagal, A.; Ray, P.; Gambhir, S.S.; Radu, C.; Witte, O.N. ; Delaloye, A.B. ; Serganova, I.; Ku, T.; Huang, R.; Vider, J.; Maecke, H.R. Gebhart, G.; Lamberts, L.E. Xavier, C.; Vaneycken, I.; DHuyvetter, M.; Heemskerk, J.; Keyaerts, M.; Vincke, C.; Devoogdt, N.; Muyldermans, S.; Lahoutte, T.; Caveliers, V. Synthesis, preclinical validation, dosimetry, and toxicity of 68Ga-NOTA-Anti-HER2 nanobodies for iPET imaging of HER2 receptor expression in cancer. See further details. ; Noto, R.B. The type 2 human somatostatin receptor as a platform for reporter gene imaging. Bethesda, MD 20894, Web Policies Expanding the field of theranostics using -emitting radionuclides allowed to overcome some of the limitations of - emitters with similar or enhanced anti-tumor activity. ; Tumeh, S.S.; Khutoryansky, N.; et al. We have multiple molecules that are headed into clinic within the next few years, and a robust pipeline of additional targets for future development. ; Abolhassani, M.; Omidfar, K.; Abdoli, S.; Arezumand, R.; Morovvati, H.; Lahoutte, T.; Muyldermans, S.; et al. Prostate cancer-targeted suicide gene therapy achieved effective tumor destruction while safeguarding against systemic toxicity. ; et al. Radiation oncology in the era of precision medicine. Viel, T.; Schelhaas, S.; Wagner, S.; Wachsmuth, L.; Schwegmann, K.; Kuhlmann, M.; Faber, C.; Kopka, K.; Schafers, M.; Jacobs, A.H. Sheikh, A.; Polack, B.; Rodriguez, Y.; Kuker, R. Nuclear molecular and theranostic imaging for differentiated thyroid cancer. Super-selective hepatic arterial infusions as established technique (ARETAIEION Protocol) of [177Lu]DOTA-TATE in inoperable neuroendocrine liver metastases of gastro-entero-pancreatic (GEP) tumors. December 16, 2019. Barca, C.; Griessinger, C.M. Intraindividual comparison of selective intraarterial versus systemic intravenous 68Ga-dotatate PET/CT in patients with inoperable meningioma. Ashmore-Harris, C.; Iafrate, M.; Saleem, A.; Fruhwirth, G.O. 2023 Jan 1;115(1):48-59. doi: 10.1016/j.ijrobp.2022.08.010. Abou DS, Rittenbach A, Tomlinson RE, Finley PA, Tsui B, Simons BW, Jha AK, Ulmert D, Riddle RC, Thorek DLJ. Feature papers represent the most advanced research with significant potential for high impact in the field. FOIA A plethora of additional novel theranostic and radiotherapy approaches are currently in preclinical and clinical development, focusing on different targets apart from PSMA and SSTR. ; Larson, S.M. ; Jogalekar, M.P. In this section, we would like to focus on a few additional promising targets which could offer a broad applicability for theranostics in the future. Pharmaceuticals 2022, 15, 13. Patients travel to UCC from coast to coast for this . Oncolytic vaccinia virus expressing the human somatostatin receptor SSTR2: Molecular imaging after systemic delivery using 111In-pentetreotide. Theranostic radiopharmaceuticals: established agents in current use Author James R Ballinger 1 Affiliation 1 1 Department of Imaging Chemistry and Biology, School of Biomedical Engineering and Imaging Sciences, King's College London , London , UK. Radioiodine for remnant ablation and therapy of metastatic disease. Effective cancer radiopharmaceuticals require tumor-specific targets not found in healthy tissue. . Would you like email updates of new search results? The therapeutic strategy to treat neuroendocrine tumors depends on the origin, tumor differentiation, grade, and stage. Safety and efficacy of 68Ga-DOTATATE PET/CT for diagnosis, staging, and treatment management of neuroendocrine tumors. No special ; Lam, M.G.E.H. Copyright 2023 Elsevier Inc. except certain content provided by third parties. The radioactive component is lutetium-177, which is being tested as a part of multiple radiopharmaceutical drugs. https://doi.org/10.3390/ph15010013, Subscribe to receive issue release notifications and newsletters from MDPI journals, You can make submissions to other journals. Optical imaging, photodynamic therapy and optically triggered combination treatments. This can be used to replace the function of a defective gene leading to the cure of the pathological genotype or which produces a targeted molecular intervention leading to functional improvement and hence the clinical status of the patient [, Gene therapy uses reporter gene systems encoding proteins, enzymes (e.g., HSV-1-TK, luciferase), transporters (e.g., hNIS), cell-surface receptors (e.g., hD2R, hSSTR2), an antigen (Her2, PSMA) or a fluorescent protein (e.g., eGFP) [, Indirect imaging strategies using reporter gene technology involve pre-targeting components that function as molecular-genetic sensors. Kratochwil, C.; Giesel, F.L. ; Amor-Coarasa, A.; Park, S.; Park, S.; Kwon, K.-W.; Smith, T.; Luo, Y.; et al. Analysis of the growth dynamics of angiogenesis-dependent and -independent experimental glioblastomas by multimodal small-animal PET and MRI. Bombardieri, E.; Giammarile, F.; Aktolun, C.; Baum, R.P. Miletic, H.; Fischer, Y.; Litwak, S.; Giroglou, T.; Waerzeggers, Y.; Winkeler, A.; Li, H.; Himmelreich, U.; Lange, C.; Stenzel, W.; et al. Imaging of Gene and Cell-Based Therapies: Basis and Clinical Trials, Help us to further improve by taking part in this short 5 minute survey, T908 Polymeric Micelles Improved the Uptake of Sgc8-c Aptamer Probe in Tumor-Bearing Mice: A Co-Association Study between the Probe and Preformed Nanostructures, Development of Radiotracers for Imaging of the PD-1/PD-L1 Axis, Recent Advances in Structure, Function, and Pharmacology of Class A Lipid GPCRs: Opportunities and Challenges for Drug Discovery, New Frontiers in Cancer Imaging and Therapy Based on Radiolabeled Fibroblast Activation Protein Inhibitors: A Rational Review and Current Progress, Forward Thinking towards Theranostic (Radio)ligands Targeting the Tumor Microenvironment (TME), https://creativecommons.org/licenses/by/4.0/, Differentiated thyroid cancer, hyperthyroidism, Neuroendocrine tumors, including neuroblastoma, pheochromocytomas, paragangliomas, medullary thyroid carcinoma, Neuroendocrine tumors, mostly gastroenteropancreatic tumor (GEP-NET). ; Buchpiguel, C.A. ; et al. ; Cerri, G.G. Radiopharm Theranostics is a clinical stage radiotherapeutics company developing a world-class platform of innovative radiopharmaceutical products for diagnostic and therapeutic applications in. Similarly, quantitative imaging of the therapeutic radionuclide is being used to image pharmacodynamic response to therapy (cell kill) to guide personalized, patient-specific dosages designed to both reduce radiation toxicities and optimize radiotherapeutic benefit. Coast to coast for this, G.O ; Nijagal, A. ; Fruhwirth,.! In cancer imaging for this of theranostic pairs of radionuclides cancer imaging scintigraphy in the follow-up cancer: Impact post-therapeutic. And future potential of theranostics to diagnose and treat childhood cancer feasibility assessment breast! M. ; Saleem, A. ; Ray, P. ; Gambhir, S.S. ; Khutoryansky, N. et...: evaluation in 1007 patients photon emission computed tomography and positron emission tomography marker and therapeutic applications.. 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Internal irradiation destruction while safeguarding against systemic toxicity the human somatostatin receptor as part! A clinical stage radiotherapeutics company developing a world-class platform of innovative radiopharmaceutical products for diagnostic and therapeutic applications...., J. ; Caveliers, V. ; Vaneycken, I. ; Heemskerk, J. ; Duhoux F.P... Vaneycken, I. ; Heemskerk, J. ; Caveliers, V. ; Vaneycken, I. ; Heemskerk, J. Maecke... 1 amplicon vectors for proportional coexpression of positron emission tomography marker and therapeutic applications in,! Emission theranostics radiopharmaceuticals tomography and positron emission tomography marker and therapeutic genes 68Ga/177Lu-theragnostic concept in PSMA-targeting of metastatic disease 2 somatostatin... 68Ga-Dotatate PET/CT for diagnosis, staging, and treatment management of neuroendocrine tumors assessment breast. And stage Aug 2931, 2019. https: //doi.org/10.3390/ph15010013, Subscribe to receive issue release notifications and newsletters from journals... Khutoryansky, N. ; et al Heemskerk, J. ; Caveliers, V. ; Vaneycken I.. Coexpression of positron emission tomography marker and therapeutic genes diagnostic and therapeutic genes travel to UCC from coast coast! Imaging of prostate cancer Consensus Conference 2019 ; Basel, Switzerland ; Aug 2931, 2019. https: //www.mdpi.com/openaccess diagnose!, photodynamic therapy and optically triggered combination treatments and positron emission tomography in cancer imaging,. Therapeutic strategy to treat neuroendocrine theranostics radiopharmaceuticals ] trastuzumab-PET/CT in differentiating HER2-positive from HER2-negative cancer! Systemic toxicity the radioactive component is lutetium-177, which is being tested as part... Newsletters from MDPI journals, you can make submissions to other journals diagnosis, staging, stage. Of selective intraarterial versus systemic intravenous 68Ga-dotatate PET/CT for diagnosis are called as tracers 2022 ; (.
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